Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease | Zendy

Alexia Hulin | Zendy; Lindsey J. Anstine | Zendy; Andrew J. Kim | Zendy; Sarah J. Potter | Zendy; Tony DeFalco | Zendy; Joy Lincoln | Zendy; Katherine E. Yutzey | Zendy

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Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease

Author(s) -

Alexia Hulin,

Lindsey J. Anstine,

Andrew J. Kim,

Sarah J. Potter,

Tony DeFalco,

Joy Lincoln,

Katherine E. Yutzey

Publication year - 2018

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.310667

Subject(s) - macrophage , biology , heart valve , chemokine , immunostaining , myeloid , immunology , pathology , microbiology and biotechnology , inflammation , medicine , immunohistochemistry , biochemistry , in vitro

Hematopoietic-derived cells have been reported in heart valves but remain poorly characterized. Interestingly, recent studies reveal infiltration of leukocytes and increased macrophages in human myxomatous mitral valves. Nevertheless, timing and contribution of macrophages in normal valves and myxomatous valve disease are still unknown. The objective is to characterize leukocytes during postnatal heart valve maturation and identify macrophage subsets in myxomatous valve disease.

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