Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages | Zendy

Tadayoshi Karasawa | Zendy; Akira Kawashima | Zendy; Fumitake UsuiKawanishi | Zendy; Sachiko Watanabe | Zendy; Hiroaki Kimura | Zendy; Ryo Kamata | Zendy; Koumei Shirasuna | Zendy; Yutaro Koyama | Zendy; Ayana Tomita | Zendy; Takashi Matsuzaka | Zendy; Hiroshi Tomoda | Zendy; SamYong Park | Zendy; Naoya Shibayama | Zendy; Hitoshi Shimano | Zendy; Tadashi Kasahara | Zendy; Masafumi Takahashi | Zendy

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Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages

Author(s) -

Tadayoshi Karasawa,

Akira Kawashima,

Fumitake UsuiKawanishi,

Sachiko Watanabe,

Hiroaki Kimura,

Ryo Kamata,

Koumei Shirasuna,

Yutaro Koyama,

Ayana Tomita,

Takashi Matsuzaka,

Hiroshi Tomoda,

SamYong Park,

Naoya Shibayama,

Hitoshi Shimano,

Tadashi Kasahara,

Masafumi Takahashi

Publication year - 2018

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.310581

Subject(s) - inflammasome , intracellular , inflammation , crystallization , pyrin domain , chemistry , microbiology and biotechnology , palmitic acid , oleic acid , biochemistry , fatty acid , biology , receptor , immunology , organic chemistry

Inflammation provoked by the imbalance of fatty acid composition, such as excess saturated fatty acids (SFAs), is implicated in the development of metabolic diseases. Recent investigations suggest the possible role of the NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain containing 3) inflammasome, which regulates IL-1β (interleukin 1β) release and leads to inflammation, in this process. Therefore, we investigated the underlying mechanism by which SFAs trigger NLRP3 inflammasome activation.

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