Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA–DNA Hybrids | Zendy

Hansjörg Schwertz | Zendy; Jesse W. Rowley | Zendy; Gerald G. Schumann | Zendy; Ulrike Thorack | Zendy; Robert A. Campbell | Zendy; Bhanu Kanth Manne | Zendy; Guy A. Zimmerman | Zendy; Andrew S. Weyrich | Zendy; Matthew T. Rondina | Zendy

Open Access

Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA–DNA Hybrids

Author(s) -

Hansjörg Schwertz,

Jesse W. Rowley,

Gerald G. Schumann,

Ulrike Thorack,

Robert A. Campbell,

Bhanu Kanth Manne,

Guy A. Zimmerman,

Andrew S. Weyrich,

Matthew T. Rondina

Publication year - 2018

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.310552

Subject(s) - reverse transcriptase , rna , dna , biology , endogeny , microbiology and biotechnology , virology , genetics , gene , biochemistry

One source of endogenous reverse transcriptase (eRT) activity in nucleated cells is the LINE-1/L1 (long interspersed nuclear element-1), a non-LTR retrotransposon that is implicated in the regulation of gene expression. Nevertheless, the presence and function of eRT activity and LINE-1 in human platelets, an anucleate cell, has not previously been determined.

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