Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways | Zendy

Tetsushi Nakao | Zendy; Takahiro Horie | Zendy; Osamu Baba | Zendy; Masataka Nishiga | Zendy; Tomohiro Nishino | Zendy; Masayasu Izuhara | Zendy; Yasuhide Kuwabara | Zendy; Hitoo Nishi | Zendy; Shunsuke Usami | Zendy; Fumiko Nakazeki | Zendy; Yuya Ide | Zendy; Satoshi Koyama | Zendy; Masahiro Kimura | Zendy; Naoya Sowa | Zendy; Satoko Ohno | Zendy; Hiroki Aoki | Zendy; Koji Hasegawa | Zendy; Kazuhisa Sakamoto | Zendy; Kenji Minatoya | Zendy; Takeshi Kimura | Zendy; Koh Ono | Zendy

Open Access

Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways

Author(s) -

Tetsushi Nakao,

Takahiro Horie,

Osamu Baba,

Masataka Nishiga,

Tomohiro Nishino,

Masayasu Izuhara,

Yasuhide Kuwabara,

Hitoo Nishi,

Shunsuke Usami,

Fumiko Nakazeki,

Yuya Ide,

Satoshi Koyama,

Masahiro Kimura,

Naoya Sowa,

Satoko Ohno,

Hiroki Aoki,

Koji Hasegawa,

Kazuhisa Sakamoto,

Kenji Minatoya,

Takeshi Kimura,

Koh Ono

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309768

Subject(s) - inflammation , microrna , abdominal aortic aneurysm , ablation , aortic aneurysm , medicine , aneurysm , pathology , cardiology , biology , surgery , gene , genetics

Abdominal aortic aneurysm (AAA) is an increasingly prevalent and ultimately fatal disease with no effective pharmacological treatment. Because matrix degradation induced by vascular inflammation is the major pathophysiology of AAA, attenuation of this inflammation may improve its outcome. Previous studies suggested that miR-33 (microRNA-33) inhibition and genetic ablation of miR-33 increased serum high-density lipoprotein cholesterol and attenuated atherosclerosis.

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