ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels | Zendy

Laia TriguerosMotos | Zendy; Julian C. van Capelleveen | Zendy; Federico Torta | Zendy; David Castaño | Zendy; Linhua Zhang | Zendy; Ee Chu Chai | Zendy; Martin H. Kang | Zendy; Lidiya G. Dimova | Zendy; Alinda W.M. Schimmel | Zendy; Ian Tietjen | Zendy; Chris Radomski | Zendy; Liang Juin Tan | Zendy; Chung Hwee Thiam | Zendy; Pradeep Narayanaswamy | Zendy; Daniel Heqing Wu | Zendy; Fabian Dorninger | Zendy; Gopala K. Yakala | Zendy; Amina Barhdadi | Zendy; Véronique Angeli | Zendy; MariePierre Dubé | Zendy; Johannes Berger | Zendy; Geesje M. DallingaThie | Zendy; Uwe J.F. Tietge | Zendy; Markus R. Wenk | Zendy; Michael R. Hayden | Zendy; G. Kees Hovingh | Zendy; Roshni R. Singaraja | Zendy

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ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels

Author(s) -

Laia TriguerosMotos,

Julian C. van Capelleveen,

Federico Torta,

David Castaño,

Linhua Zhang,

Ee Chu Chai,

Martin H. Kang,

Lidiya G. Dimova,

Alinda W.M. Schimmel,

Ian Tietjen,

Chris Radomski,

Liang Juin Tan,

Chung Hwee Thiam,

Pradeep Narayanaswamy,

Daniel Heqing Wu,

Fabian Dorninger,

Gopala K. Yakala,

Amina Barhdadi,

Véronique Angeli,

MariePierre Dubé,

Johannes Berger,

Geesje M. DallingaThie,

Uwe J.F. Tietge,

Markus R. Wenk,

Michael R. Hayden,

G. Kees Hovingh,

Roshni R. Singaraja

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309574

Subject(s) - efflux , cholesterol , reverse cholesterol transport , abca1 , atp binding cassette transporter , biology , high density lipoprotein , apolipoprotein b , transporter , atp binding cassette transporter 1 , mutant , adenosine triphosphate , lipoprotein , endocrinology , medicine , chemistry , biochemistry , gene

High-density lipoproteins (HDL) are considered to protect against atherosclerosis in part by facilitating the removal of cholesterol from peripheral tissues. However, factors regulating lipid efflux are incompletely understood. We previously identified a variant in adenosine triphosphate-binding cassette transporter A8 ( ABCA8 ) in an individual with low HDL cholesterol (HDLc). Here, we investigate the role of ABCA8 in cholesterol efflux and in regulating HDLc levels.

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