DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to Atherosclerosis | Zendy

Yukako Kayashima | Zendy; Natalia Makhanova | Zendy; Nobuyo Maeda | Zendy

Open Access

DBA/2J Haplotype on Distal Chromosome 2 Reduces Mertk Expression, Restricts Efferocytosis, and Increases Susceptibility to Atherosclerosis

Author(s) -

Yukako Kayashima,

Natalia Makhanova,

Nobuyo Maeda

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309522

Subject(s) - mertk , efferocytosis , gas6 , biology , phagocytosis , thymic involution , microbiology and biotechnology , receptor tyrosine kinase , cancer research , immunology , genetics , immune system , kinase , macrophage , t cell , in vitro

Arch atherosclerosis 4 ( Aath4 ) is a quantitative trait locus for atherosclerotic plaque formation in the inner curve of the aortic arch previously identified in an F2 cross of Apoe -/- mice on DBA/2J and 129S6 backgrounds. C-mer proto-oncogene tyrosine kinase (Mertk ), coding for a ligand-activated transmembrane tyrosine kinase, is a candidate gene within the same chromosomal region. Our objective was to determine whether strain differences in Mertk influence plaque formation.

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