Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation | Zendy

Adelina Curaj | Zendy; Zhuojun Wu | Zendy; Anne Rix | Zendy; Oliver Gresch | Zendy; Marieke Sternkopf | Zendy; Setareh AlampourRajabi | Zendy; Twan Lammers | Zendy; Marc van Zandvoort | Zendy; Christian Weber | Zendy; Rory R. Koenen | Zendy; Elisa A. Liehn | Zendy; Fabian Kießling | Zendy

Open Access

Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation

Author(s) -

Adelina Curaj,

Zhuojun Wu,

Anne Rix,

Oliver Gresch,

Marieke Sternkopf,

Setareh AlampourRajabi,

Twan Lammers,

Marc van Zandvoort,

Christian Weber,

Rory R. Koenen,

Elisa A. Liehn,

Fabian Kießling

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309503

Subject(s) - cell adhesion molecule , blood flow , endothelium , endothelial activation , microbiology and biotechnology , adhesion , intercellular adhesion molecule 1 , pathology , medicine , biology , chemistry , organic chemistry

The junctional adhesion molecule A (JAM-A) is physiologically located in interendothelial tight junctions and focally redistributes to the luminal surface of blood vessels under abnormal shear and flow conditions accompanying atherosclerotic lesion development. Therefore, JAM-A was evaluated as a target for molecularly targeted ultrasound imaging of transient endothelial dysfunction under acute blood flow variations.

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