Circulating Levels of Interleukin 1-Receptor Antagonist and Risk of Cardiovascular Disease | Zendy

Christian Herder | Zendy; Tonia de las Heras Gala | Zendy; Maren CarstensenKirberg | Zendy; Cornelia Huth | Zendy; Astrid Zierer | Zendy; Simone Wahl | Zendy; Julie Sudduth-Klinger | Zendy; Kari Kuulasmaa | Zendy; David Peretz | Zendy; Symen Ligthart | Zendy; Brenda Bongaerts | Zendy; Abbas Dehghan | Zendy; M. Arfan Ikram | Zendy; Antti Jula | Zendy; Frank Kee | Zendy; Arto Pietilä | Zendy; Olli Saarela | Zendy; Tanja Zeller | Zendy; Stefan Blankenberg | Zendy; Christa Meisinger | Zendy; Annette Peters | Zendy; Michael Roden | Zendy; Veikko Salomaa | Zendy; Wolfgang Köenig | Zendy; Barbara Thorand | Zendy

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Circulating Levels of Interleukin 1-Receptor Antagonist and Risk of Cardiovascular Disease

Author(s) -

Christian Herder,

Tonia de las Heras Gala,

Maren CarstensenKirberg,

Cornelia Huth,

Astrid Zierer,

Simone Wahl,

Julie Sudduth-Klinger,

Kari Kuulasmaa,

David Peretz,

Symen Ligthart,

Brenda Bongaerts,

Abbas Dehghan,

M. Arfan Ikram,

Antti Jula,

Frank Kee,

Arto Pietilä,

Olli Saarela,

Tanja Zeller,

Stefan Blankenberg,

Christa Meisinger,

Annette Peters,

Michael Roden,

Veikko Salomaa,

Wolfgang Köenig,

Barbara Thorand

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309307

Subject(s) - interleukin 1 receptor antagonist , medicine , hazard ratio , cohort , confounding , receptor antagonist , meta analysis , population , confidence interval , cohort study , disease , antagonist , environmental health , receptor

Interleukin (IL)-1β represents a key cytokine in the development of cardiovascular disease (CVD). IL-1β is counter-regulated by IL-1 receptor antagonist (IL-1RA), an endogenous inhibitor. This study aimed to identify population-based studies on circulating IL-1RA and incident CVD in a systematic review, estimate the association between IL-1RA and incident CVD in a meta-analysis, and to test whether the association between IL-1RA and incident CVD is explained by other inflammation-related biomarkers in the MONICA/KORA Augsburg case-cohort study (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease/Cooperative Health Research in the Region of Augsburg).

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