Open AccessResponse by Takase and Matoba to Letter Regarding Article, “Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial”
Author(s) -
Susumu Takase,
Tetsuya Matoba
Publication year - 2017
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.117.309301
Subject(s) - ezetimibe , medicine , coronary arteries , cardiology , endothelial dysfunction , coronary stenting , statin , cholesterol , pharmacology , stent , artery , restenosis
We appreciate the letter regarding our recently published CuVIC trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting).1 As pointed, our notion that the improvement of coronary endothelial function in the ezetimibe plus statin treatment arm compared with statin alone arm might owe to the reductions in oxysterols was based on a post hoc analysis. In the analysis, we generated subgroups (n=62 each) by matching on-treatment low-density lipoprotein cholesterol (LDL-C) levels from the 2 treatment arms; therefore, it was important to assess baseline characteristics of the subgroups. Between the 2 on-treatment LDL-C–matched subgroups, there were no significant differences at the baseline, in background characteristics (sex, age, systolic blood pressure, and ejection fraction) and coronary risk factors (hypertension, diabetes mellitus, dyslipidemia, family …
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