Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets | Zendy

Christopher W. Smith | Zendy; Steven G. Thomas | Zendy; Zaher Raslan | Zendy; Pushpa Patel | Zendy; Maxwell Byrne | Zendy; Marie Lordkipanidzé | Zendy; Danai Bem | Zendy; Linde Meyaard | Zendy; Yotis A. Senis | Zendy; Steve P. Watson | Zendy; Alexandra Mazharian | Zendy

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Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets

Author(s) -

Christopher W. Smith,

Steven G. Thomas,

Zaher Raslan,

Pushpa Patel,

Maxwell Byrne,

Marie Lordkipanidzé,

Danai Bem,

Linde Meyaard,

Yotis A. Senis,

Steve P. Watson,

Alexandra Mazharian

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309253

Subject(s) - platelet , immunoreceptor tyrosine based activation motif , integrin , proto oncogene tyrosine protein kinase src , platelet activation , signal transduction , chemistry , microbiology and biotechnology , megakaryocyte , tyrosine kinase , receptor , syk , lyn , cancer research , biology , immunology , haematopoiesis , biochemistry , stem cell

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a collagen receptor that belongs to the inhibitory immunoreceptor tyrosine-based inhibition motif-containing receptor family. It is an inhibitor of signaling via the immunoreceptor tyrosine-based activation motif-containing collagen receptor complex, glycoprotein VI-FcRγ-chain. It is expressed on hematopoietic cells, including immature megakaryocytes, but is not detectable on platelets. Although the inhibitory function of LAIR-1 has been described in leukocytes, its physiological role in megakaryocytes and in particular in platelet formation has not been explored. In this study, we investigate the role of LAIR-1 in megakaryocyte development and platelet production by generating LAIR-1-deficient mice.

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