Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites | Zendy

Shuang Feng | Zendy; Neil Bowden | Zendy; Maria Fragiadaki | Zendy; Céline Souilhol | Zendy; Sarah Hsiao | Zendy; Marwa Mahmoud | Zendy; Scott P. Allen | Zendy; Daniela Pirri | Zendy; Blanca Tardajos Ayllón | Zendy; Shamima Akhtar | Zendy; A. A. Roger Thompson | Zendy; Hanjoong Jo | Zendy; Christian Weber | Zendy; Victoria Ridger | Zendy; Andreas Schober | Zendy; Paul C. Evans | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites

Author(s) -

Shuang Feng,

Neil Bowden,

Maria Fragiadaki,

Céline Souilhol,

Sarah Hsiao,

Marwa Mahmoud,

Scott P. Allen,

Daniela Pirri,

Blanca Tardajos Ayllón,

Shamima Akhtar,

A. A. Roger Thompson,

Hanjoong Jo,

Christian Weber,

Victoria Ridger,

Andreas Schober,

Paul C. Evans

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309249

Subject(s) - hypoxia (environmental) , hypoxia inducible factors , endothelial dysfunction , medicine , cardiology , biology , endocrinology , chemistry , microbiology and biotechnology , biochemistry , gene , oxygen , organic chemistry

Atherosclerosis develops near branches and bends of arteries that are exposed to low shear stress (mechanical drag). These sites are characterized by excessive endothelial cell (EC) proliferation and inflammation that promote lesion initiation. The transcription factor HIF1α (hypoxia-inducible factor 1α) is canonically activated by hypoxia and has a role in plaque neovascularization. We studied the influence of shear stress on HIF1α activation and the contribution of this noncanonical pathway to lesion initiation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research