RXR Ligands Negatively Regulate Thrombosis and Hemostasis | Zendy

Amanda J. Unsworth | Zendy; Gagan D. Flora | Zendy; Parvathy Sasikumar | Zendy; Alexander P. Bye | Zendy; Tanya Sage | Zendy; Neline Kriek | Zendy; Marilena Crescente | Zendy; Jonathan M. Gibbins | Zendy

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RXR Ligands Negatively Regulate Thrombosis and Hemostasis

Author(s) -

Amanda J. Unsworth,

Gagan D. Flora,

Parvathy Sasikumar,

Alexander P. Bye,

Tanya Sage,

Neline Kriek,

Marilena Crescente,

Jonathan M. Gibbins

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309207

Subject(s) - gpvi , retinoic acid , platelet , platelet activation , retinoid x receptor , chemistry , microbiology and biotechnology , thromboxane a2 , collagen receptor , biochemistry , integrin , receptor , biology , nuclear receptor , immunology , transcription factor , gene

Platelets have been found to express intracellular nuclear receptors including the retinoid X receptors (RXRα and RXRβ). Treatment of platelets with ligands of RXR has been shown to inhibit platelet responses to ADP and thromboxane A2; however, the effects on responses to other platelet agonists and the underlying mechanism have not been fully characterized.

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