Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition | Zendy

Elmar Pieterse | Zendy; Nils Rother | Zendy; Marjolein Garsen | Zendy; Julia M. Hofstra | Zendy; Simon C. Satchell | Zendy; Markus Hoffmann | Zendy; Markus A. Loeven | Zendy; Hanneke Knaapen | Zendy; Olivier W.H. van der Heijden | Zendy; Jo H. M. Berden | Zendy; Luuk B. Hilbrands | Zendy; Johan van der Vlag | Zendy

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Neutrophil Extracellular Traps Drive Endothelial-to-Mesenchymal Transition

Author(s) -

Elmar Pieterse,

Nils Rother,

Marjolein Garsen,

Julia M. Hofstra,

Simon C. Satchell,

Markus Hoffmann,

Markus A. Loeven,

Hanneke Knaapen,

Olivier W.H. van der Heijden,

Jo H. M. Berden,

Luuk B. Hilbrands,

Johan van der Vlag

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.117.309002

Subject(s) - neutrophil extracellular traps , endothelial stem cell , endothelium , endothelial dysfunction , microbiology and biotechnology , neutrophil elastase , mesenchymal stem cell , biology , chemistry , immunology , inflammation , endocrinology , biochemistry , in vitro

An excessive release and impaired degradation of neutrophil extracellular traps (NETs) leads to the continuous exposure of NETs to the endothelium in a variety of hematologic and autoimmune disorders, including lupus nephritis. This study aims to unravel the mechanisms through which NETs jeopardize vascular integrity.

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