Serotonin Signaling Through the 5-HT 1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension | Zendy

Katie Y Hood | Zendy; Kirsty M. Mair | Zendy; Adam Harvey | Zendy; Augusto C. Montezano | Zendy; Rhian M. Touyz | Zendy; Margaret R. MacLean | Zendy

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Serotonin Signaling Through the 5-HT _1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension

Author(s) -

Katie Y Hood,

Kirsty M. Mair,

Adam Harvey,

Augusto C. Montezano,

Rhian M. Touyz,

Margaret R. MacLean

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308929

Subject(s) - nox1 , nadph oxidase , oxidative stress , serotonin transporter , endocrinology , medicine , serotonin , reactive oxygen species , chemistry , vascular smooth muscle , biology , microbiology and biotechnology , pharmacology , receptor , smooth muscle

Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesize that in PASMCs, serotonin induces oxidative stress through NADPH-oxidase-derived ROS generation and reduced Nrf-2 (nuclear factor [erythroid-derived 2]-like 2) antioxidant systems, promoting vascular injury.

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