The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation | Zendy

Yunfei Yan | Zendy; Jian-Fei Pei | Zendy; Yang Zhang | Zendy; Ran Zhang | Zendy; Fang Wang | Zendy; Peng Gao | Zendy; ZhuQin Zhang | Zendy; Tingting Wang | Zendy; ZhiGang She | Zendy; HouZao Chen | Zendy; DePei Liu | Zendy

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The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation

Author(s) -

Yunfei Yan,

Jian-Fei Pei,

Yang Zhang,

Ran Zhang,

Fang Wang,

Peng Gao,

ZhuQin Zhang,

Tingting Wang,

ZhiGang She,

HouZao Chen,

DePei Liu

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308684

Subject(s) - abdominal aortic aneurysm , paraoxonase , aryldialkylphosphatase , cluster (spacecraft) , aortic aneurysm , cardiology , medicine , gene cluster , aneurysm , gene , pon1 , biology , surgery , aorta , genetics , computer science , oxidative stress , genotype , programming language

Abdominal aortic aneurysm (AAA) is a life-threatening vascular pathology, the pathogenesis of which is closely related to oxidative stress. However, an effective pharmaceutical treatment is lacking because the exact cause of AAA remains unknown. Here, we aimed at delineating the role of the paraoxonases (PONs) gene cluster (PC), which prevents atherosclerosis through the detoxification of oxidized substrates, in AAA formation.

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