Contraction of Blood Clots Is Impaired in Acute Ischemic Stroke | Zendy

Valerie Tutwiler | Zendy; Alina D. Peshkova | Zendy; Izabella A. Andrianova | Zendy; Д. Р. Хасанова | Zendy; John W. Weisel | Zendy; Rustem I. Litvinov | Zendy

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Contraction of Blood Clots Is Impaired in Acute Ischemic Stroke

Author(s) -

Valerie Tutwiler,

Alina D. Peshkova,

Izabella A. Andrianova,

Д. Р. Хасанова,

John W. Weisel,

Rustem I. Litvinov

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308622

Subject(s) - medicine , thrombus , cardiology , contraction (grammar) , platelet , stroke (engine) , clot retraction , blood volume , ischemia , thrombin , mechanical engineering , engineering

Obstructive thrombi or thrombotic emboli are the pathogenic basis of ischemic stroke. In vitro blood clots and in vivo thrombi can undergo platelet-driven contraction (retraction), resulting in volume shrinkage. Clot contraction can potentially reduce vessel occlusion and improve blood flow past emboli or thrombi. The aim of this work was to examine a potential pathogenic role of clot contraction in ischemic stroke.

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