Map3k8 Modulates Monocyte State and Atherogenesis in ApoE −/− Mice | Zendy

Carlos SanzGarcía | Zendy; Ángela Sánchez | Zendy; Constanza ContrerasJurado | Zendy; Carmela Calés | Zendy; Cristina Barranquero | Zendy; Marta Muñoz | Zendy; Ramón Merino | Zendy; Paula Escudero | Zendy; MaríaJesús Sanz | Zendy; Jesús Osada | Zendy; Ana Aranda | Zendy; Susana Alemany | Zendy

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Map3k8 Modulates Monocyte State and Atherogenesis in ApoE ^−/− Mice

Author(s) -

Carlos SanzGarcía,

Ángela Sánchez,

Constanza ContrerasJurado,

Carmela Calés,

Cristina Barranquero,

Marta Muñoz,

Ramón Merino,

Paula Escudero,

MaríaJesús Sanz,

Jesús Osada,

Ana Aranda,

Susana Alemany

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308528

Subject(s) - monocyte , state (computer science) , apolipoprotein e , immunology , medicine , biology , computer science , disease , algorithm

Map3k8 (Cot/Tpl2) activates the MKK1/2-ERK1/2, MAPK pathway downstream from interleukin-1R, tumor necrosis factor-αR, NOD-2R (nucleotide-binding oligomerization domain-like 2R), adiponectinR, and Toll-like receptors. Map3k8 plays a key role in innate and adaptive immunity and influences inflammatory processes by modulating the functions of different cell types. However, its role in atherogenesis remains unknown. In this study, we analyzed the role of this kinase in this pathology.

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