Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability | Zendy

Rende Xu | Zendy; Chenguang Li | Zendy; Yizhe Wu | Zendy; Li Shen | Zendy; Jianying Ma | Zendy; Juying Qian | Zendy; Junbo Ge | Zendy

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Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability

Author(s) -

Rende Xu,

Chenguang Li,

Yizhe Wu,

Li Shen,

Jianying Ma,

Juying Qian,

Junbo Ge

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308461

Subject(s) - macrophage polarization , proinflammatory cytokine , macrophage , microbiology and biotechnology , inflammation , cancer research , biology , immunology , in vitro , biochemistry

Emerging evidence indicates that proinflammatory macrophage polarization imbalance plays a key role in atherosclerotic plaque progression and instability. The calcium-activated potassium channel KCa3.1 is critically involved in macrophage activation and function. However, the role of KCa3.1 in macrophage polarization is unknown. This study investigates the potential role of KCa3.1 in transcriptional regulation in macrophage polarization and its relationship to plaque instability.

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