Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury–Induced Neointimal Hyperplasia | Zendy

Qing Ye | Zendy; Alice Pang | Zendy; Wenjing Zhang | Zendy; Xiaotong Guo | Zendy; Jianli Wang | Zendy; Yongtao Zhang | Zendy; Yang Liu | Zendy; Xiao Wu | Zendy; Fan Jiang | Zendy

Open Access

Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury–Induced Neointimal Hyperplasia

Author(s) -

Qing Ye,

Alice Pang,

Wenjing Zhang,

Xiaotong Guo,

Jianli Wang,

Yongtao Zhang,

Yang Liu,

Xiao Wu,

Fan Jiang

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308401

Subject(s) - neointima , ribosome biogenesis , cancer research , apoptosis , phosphorylation , neointimal hyperplasia , cell cycle , cell growth , biology , ataxia telangiectasia , dna damage , restenosis , microbiology and biotechnology , medicine , biochemistry , rna , dna , ribosome , stent , gene

RNA polymerase I (Pol I)-dependent rRNA synthesis is a determinant factor in ribosome biogenesis and thus cell proliferation. The importance of dysregulated Pol I activity in cardiovascular disease, however, has not been recognized. Here, we tested the hypothesis that specific inhibition of Pol I might prevent arterial injury-induced neointimal hyperplasia.

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