MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression | Zendy

Shanming Deng | Zendy; Huilan Wang | Zendy; Chunling Jia | Zendy; Shoukang Zhu | Zendy; Xianming Chu | Zendy; Qi Ma | Zendy; Jianqin Wei | Zendy; Emily Chen | Zendy; Wei Zhu | Zendy; Conrad Macon | Zendy; Dushyantha Jayaweera | Zendy; Derek M. Dykxhoorn | Zendy; Chunming Dong | Zendy

Open Access

MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression

Author(s) -

Shanming Deng,

Huilan Wang,

Chunling Jia,

Shoukang Zhu,

Xianming Chu,

Qi Ma,

Jianqin Wei,

Emily Chen,

Wei Zhu,

Conrad Macon,

Dushyantha Jayaweera,

Derek M. Dykxhoorn,

Chunming Dong

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308378

Subject(s) - senescence , apoptosis , microbiology and biotechnology , biology , microrna , cancer research , bone marrow , progenitor cell , kinase , angiogenesis , programmed cell death , stem cell , immunology , genetics , gene

Lineage-negative bone marrow cells (lin- BMCs) are enriched in endothelial progenitor cells and mediate vascular repair. Aging-associated senescence and apoptosis result in reduced number and functionality of lin- BMCs, impairing their prorepair capacity. The molecular mechanisms underlying lin- BMC senescence and apoptosis are poorly understood. MicroRNAs (miRNAs) regulate many important biological processes. The identification of miRNA-mRNA networks that modulate the health and functionality of lin- BMCs is a critical step in understanding the process of vascular repair. The aim of this study was to characterize the role of the miR-146a-Polo-like kinase 2 (Plk2) network in regulating lin- BMC senescence, apoptosis, and their angiogenic capability.

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