Reverse Cholesterol Transport Is Increased in Germ-Free Mice—Brief Report | Zendy

Rima H. Mistry | Zendy; Henkjan J. Verkade | Zendy; Uwe J.F. Tietge | Zendy

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Reverse Cholesterol Transport Is Increased in Germ-Free Mice—Brief Report

Author(s) -

Rima H. Mistry,

Henkjan J. Verkade,

Uwe J.F. Tietge

Publication year - 2017

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308306

Subject(s) - cholesterol , bile acid , feces , reverse cholesterol transport , medicine , excretion , endocrinology , biology , gut flora , sterol , in vivo , metabolism , biochemistry , microbiology and biotechnology , lipoprotein

The intestinal microbiota is emerging as a clinically relevant modulator of atherosclerotic risk. Reverse cholesterol transport (RCT) is an atheroprotective metabolic pathway. How the microbiota impacts RCT has not been investigated. Therefore, the aim of this study was to characterize (cholesterol) metabolism and RCT in germ-free mice compared with conventional mice.

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