Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1 | Zendy

Olivier Herbin | Zendy; Adam G. Regelmann | Zendy; Bhama Ramkhelawon | Zendy; Erica G. Weinstein | Zendy; Kathryn J. Moore | Zendy; Konstantina Alexandropoulos | Zendy

Open Access

Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1

Author(s) -

Olivier Herbin,

Adam G. Regelmann,

Bhama Ramkhelawon,

Erica G. Weinstein,

Kathryn J. Moore,

Konstantina Alexandropoulos

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.308014

Subject(s) - monocyte , bone marrow , haematopoiesis , cell adhesion , inflammation , cell adhesion molecule , biology , signal transducing adaptor protein , myeloid , immunology , microbiology and biotechnology , cell , stem cell , signal transduction , biochemistry

The chronic inflammation associated with atherosclerosis is caused by lipid deposition followed by leukocyte recruitment to the arterial wall. We previously showed that the hematopoietic cell-specific adaptor protein Cas- and Hef1-associated signal transducer hematopoietic isoform (Chat-H)/SHEP1 regulated lymphocyte adhesion and migration. In this study, we analyzed the role of Chat-H in atherosclerosis development.

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