Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy | Zendy

Yuji Oe | Zendy; Sakiko Hayashi | Zendy; Tomofumi Fushima | Zendy; Emiko Sato | Zendy; Kiyomi Kisu | Zendy; Hiroshi Satō | Zendy; Sadayoshi Ito | Zendy; Nobuyuki Takahashi | Zendy

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Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy

Author(s) -

Yuji Oe,

Sakiko Hayashi,

Tomofumi Fushima,

Emiko Sato,

Kiyomi Kisu,

Hiroshi Satō,

Sadayoshi Ito,

Nobuyuki Takahashi

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307883

Subject(s) - coagulation , diabetic nephropathy , medicine , protease , receptor , nephropathy , pharmacology , endocrinology , diabetes mellitus , immunology , chemistry , enzyme , biochemistry

The role of hypercoagulability in the pathogenesis of diabetic nephropathy (DN) remains elusive. We recently reported the increased infiltration of macrophages expressing tissue factor in diabetic kidney glomeruli; tissue factor activates coagulation factor X (FX) to FXa, which in turn stimulates protease-activated receptor 2 (PAR2) and causes inflammation.

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