Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis | Zendy

Raymond Piatt | Zendy; David S. Paul | Zendy; Robert H. Lee | Zendy; Steven E. McKenzie | Zendy; Leslie V. Parise | Zendy; Dale O. Cowley | Zendy; Brian C. Cooley | Zendy; Wolfgang Bergmeier | Zendy

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Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis

Author(s) -

Raymond Piatt,

David S. Paul,

Robert H. Lee,

Steven E. McKenzie,

Leslie V. Parise,

Dale O. Cowley,

Brian C. Cooley,

Wolfgang Bergmeier

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307874

Subject(s) - hemostasis , platelet , platelet activation , blood platelet disorders , medicine , platelet aggregation

The tight regulation of platelet adhesiveness, mediated by the αIIbβ3 integrin, is critical for hemostasis and prevention of thrombosis. We recently demonstrated that integrin affinity in platelets is controlled by the guanine nucleotide exchange factor, CalDAG-GEFI (CD-GEFI), and its target, RAP1. In this study, we investigated whether low-level expression of CD-GEFI leads to protection from thrombosis without pathological bleeding in mice.

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