AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function | Zendy

TzuPin Shentu | Zendy; Ming He | Zendy; Xiaoli Sun | Zendy; Jianlin Zhang | Zendy; Fan Zhang | Zendy; Brendan Gongol | Zendy; Traci Marin | Zendy; Jiao Zhang | Zendy; Liang Wen | Zendy; Yinsheng Wang | Zendy; Gregory G. Geary | Zendy; Yi Zhu | Zendy; David A. Johnson | Zendy; John Y.J. Shyy | Zendy

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AMP-Activated Protein Kinase and Sirtuin 1 Coregulation of Cortactin Contributes to Endothelial Function

Author(s) -

TzuPin Shentu,

Ming He,

Xiaoli Sun,

Jianlin Zhang,

Fan Zhang,

Brendan Gongol,

Traci Marin,

Jiao Zhang,

Liang Wen,

Yinsheng Wang,

Gregory G. Geary,

Yi Zhu,

David A. Johnson,

John Y.J. Shyy

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307871

Subject(s) - cortactin , sirtuin , microbiology and biotechnology , function (biology) , protein kinase a , sirtuin 1 , chemistry , biology , kinase , biochemistry , enzyme , gene , downregulation and upregulation , cytoskeleton , cell , nad+ kinase

Cortactin translocates to the cell periphery in vascular endothelial cells (ECs) on cortical-actin assembly in response to pulsatile shear stress. Because cortactin has putative sites for AMP-activated protein kinase (AMPK) phosphorylation and sirtuin 1 (SIRT1) deacetylation, we examined the hypothesis that AMPK and SIRT1 coregulate cortactin dynamics in response to shear stress.

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