Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation | Zendy

Huimin Yan | Zendy; Huifang Zhou | Zendy; Antonina Akk | Zendy; Ying S. Hu | Zendy; Luke E. Springer | Zendy; Terri L. Ennis | Zendy; Christine T. N. Pham | Zendy

Open Access

Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation

Author(s) -

Huimin Yan,

Huifang Zhou,

Antonina Akk,

Ying S. Hu,

Luke E. Springer,

Terri L. Ennis,

Christine T. N. Pham

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307786

Subject(s) - proteases , neutrophil extracellular traps , elastase , neutrophil elastase , cathelicidin , cathepsin g , cathepsin c , proteinase 3 , serine protease , serine , biology , extracellular , myeloperoxidase , pancreatic elastase , microbiology and biotechnology , immunology , biochemistry , peptide , inflammation , protease , antimicrobial peptides , enzyme

We previously established that neutrophil-derived dipeptidyl peptidase I (DPPI) is essential for experimental abdominal aortic aneurysm (AAA) development. Because DPPI activates several neutrophil serine proteases, it remains to be determined whether the AAA-promoting effect of DPPI is mediated by neutrophil serine proteases.

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