Endothelial Cell–Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor–Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation | Zendy

Nirav Dhanesha | Zendy; Prem Prakash | Zendy; Prakash Doddapattar | Zendy; Ira Khanna | Zendy; Molly Pollpeter | Zendy; Manasa K. Nayak | Zendy; Janice M. Staber | Zendy; Anil K. Chauhan | Zendy

Open Access

Endothelial Cell–Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor–Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation

Author(s) -

Nirav Dhanesha,

Prem Prakash,

Prakash Doddapattar,

Ira Khanna,

Molly Pollpeter,

Manasa K. Nayak,

Janice M. Staber,

Anil K. Chauhan

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307660

Subject(s) - von willebrand factor , adamts13 , platelet , inflammation , medicine , endocrinology , fibrin , immunology

von Willebrand factor (VWF), which is synthesized in endothelial cells and megakaryocytes, is known to worsen stroke outcome. In vitro studies suggest that platelet-derived VWF (Plt-VWF) is biochemically different from the endothelial cell-derived VWF (EC-VWF). However, little is known about relative contribution of different pools of VWF in stroke.

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