Open AccessNLRP3 (Nucleotide Oligomerization Domain–Like Receptor Family, Pyrin Domain Containing 3)–Caspase-1 Inflammasome Degrades Contractile Proteins
Author(s) -
Darrell Wu,
Pingping Ren,
Yanqiu Zheng,
Lin Zhang,
Gaiping Xu,
Wanmu Xie,
Eric E. Lloyd,
Sui Zhang,
Qianzi Zhang,
John A. Curci,
Joseph S. Coselli,
Dianna M. Milewicz,
Ying H. Shen,
Scott A. LeMaire
Publication year - 2017
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.116.307648
Subject(s) - inflammasome , pyrin domain , receptor , angiotensin ii , caspase 1 , microbiology and biotechnology , medicine , biology , endocrinology , chemistry
Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and dissection (AAD) development. However, the mechanisms underlying SMC contractile dysfunction in sporadic AAD are poorly understood. In this study, we examined the role of the NLRP3 (nucleotide oligomerization domain-like receptor family, pyrin domain containing 3)-caspase-1 inflammasome, a key inflammatory cascade, in SMC contractile dysfunction in AAD.
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