Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage | Zendy

Wenchun Chen | Zendy; Xin Liang | Zendy; Anum Syed | Zendy; Paula Jessup | Zendy; William R. Church | Zendy; Jerry Ware | Zendy; Cassandra D. Josephson | Zendy; Renhao Li | Zendy

Open Access

Inhibiting GPIbα Shedding Preserves Post-Transfusion Recovery and Hemostatic Function of Platelets After Prolonged Storage

Author(s) -

Wenchun Chen,

Xin Liang,

Anum Syed,

Paula Jessup,

William R. Church,

Jerry Ware,

Cassandra D. Josephson,

Renhao Li

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307639

Subject(s) - platelet , platelet glycoprotein gpib ix complex , platelet transfusion , platelet activation , chemistry , ex vivo , in vivo , platelet membrane glycoprotein , immunology , thrombus , von willebrand factor , medicine , biology , biochemistry , in vitro , microbiology and biotechnology

The platelet storage lesion accelerates platelet clearance after transfusion, but the underlying molecular mechanism remains elusive. Although inhibiting sheddase activity hampers clearance of platelets with storage lesion, the target platelet protein responsible for ectodomain shedding-induced clearance is not definitively identified. Monoclonal antibody 5G6 was developed recently to bind specifically human platelet receptor glycoprotein (GP)Ibα and inhibit its shedding but not shedding of other receptors. Here, the role of GPIbα shedding in platelet clearance after transfusion was addressed.

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