Neutrophil Extracellular Traps Promote Angiogenesis | Zendy

Lulwah Aldabbous | Zendy; Vahitha B. AbdulSalam | Zendy; Tom McKin | Zendy; Lucie Duluc | Zendy; Joanna PepkeŻaba | Zendy; Mark Southwood | Zendy; Alexander J. Ainscough | Zendy; Charaka Hadinnapola | Zendy; Martin R. Wilkins | Zendy; Mark Toshner | Zendy; Beata WójciakStothard | Zendy

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Neutrophil Extracellular Traps Promote Angiogenesis

Author(s) -

Lulwah Aldabbous,

Vahitha B. AbdulSalam,

Tom McKin,

Lucie Duluc,

Joanna PepkeŻaba,

Mark Southwood,

Alexander J. Ainscough,

Charaka Hadinnapola,

Martin R. Wilkins,

Mark Toshner,

Beata WójciakStothard

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307634

Subject(s) - angiogenesis , pulmonary hypertension , neutrophil elastase , neutrophil extracellular traps , endothelial stem cell , matrigel , in vivo , medicine , immunology , cancer research , biology , inflammation , in vitro , biochemistry , microbiology and biotechnology

Inflammation and dysregulated angiogenesis are features of endothelial dysfunction in pulmonary hypertension. Neutrophil extracellular traps (NETs), produced by dying neutrophils, contribute to pathogenesis of numerous vascular disorders but their role in pulmonary hypertension has not been studied. We sought evidence of (NETs) formation in pulmonary hypertension and investigated the effect of NETs on endothelial function.

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