Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration | Zendy

Helen Williams | Zendy; Carina A.E. Mill | Zendy; B.A. Monk | Zendy; Sarah L. Hulin-Curtis | Zendy; Jason L. Johnson | Zendy; Sarah J. George | Zendy

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Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration

Author(s) -

Helen Williams,

Carina A.E. Mill,

B.A. Monk,

Sarah L. Hulin-Curtis,

Jason L. Johnson,

Sarah J. George

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307626

Subject(s) - wnt signaling pathway , gene knockdown , vascular smooth muscle , cell migration , intimal hyperplasia , gene silencing , restenosis , small interfering rna , downregulation and upregulation , chemistry , cell , microbiology and biotechnology , medicine , endocrinology , signal transduction , biology , rna , biochemistry , stent , apoptosis , smooth muscle , gene

Increased vascular smooth muscle cell (VSMC) migration leads to intimal thickening which acts as a soil for atherosclersosis, as well as causing coronary artery restenosis after stenting and vein graft failure. Investigating factors involved in VSMC migration may enable us to reduce intimal thickening and improve patient outcomes. In this study, we determined whether Wnt proteins regulate VSMC migration and thereby intimal thickening.

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