Calmodulin Mediates Ca 2+ -Dependent Inhibition of Tie2 Signaling and Acts as a Developmental Brake During Embryonic Angiogenesis | Zendy

Chansik Yang | Zendy; Jiyeon Ohk | Zendy; Ji Yeun Lee | Zendy; Eunjin Kim | Zendy; Jiyoon Kim | Zendy; Sangyeul Han | Zendy; Dongeun Park | Zendy; Hosung Jung | Zendy; Chungho Kim | Zendy

Open Access

Calmodulin Mediates Ca ²⁺ -Dependent Inhibition of Tie2 Signaling and Acts as a Developmental Brake During Embryonic Angiogenesis

Author(s) -

Chansik Yang,

Jiyeon Ohk,

Ji Yeun Lee,

Eunjin Kim,

Jiyoon Kim,

Sangyeul Han,

Dongeun Park,

Hosung Jung,

Chungho Kim

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307619

Subject(s) - angiogenesis , microbiology and biotechnology , calmodulin , biology , nfat , xenopus , receptor tyrosine kinase , phosphorylation , biochemistry , cancer research , transcription factor , gene , enzyme

Angiogenesis, the process of building complex vascular structures, begins with sprout formation on preexisting blood vessels, followed by extension of the vessels through proliferation and migration of endothelial cells. Based on the potential therapeutic benefits of preventing angiogenesis in pathological conditions, many studies have focused on the mechanisms of its initiation as well as control. However, how the extension of vessels is terminated remains obscure. Thus, we investigated the negative regulation mechanism.

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