Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases | Zendy

Marilena Crescente | Zendy; Fred G. Pluthero | Zendy; Ling Li | Zendy; Richard Lo | Zendy; Tony G. Walsh | Zendy; Michael P. Schenk | Zendy; LisaMarie Holbrook | Zendy; Silvia Louriero | Zendy; Marfoua S. Ali | Zendy; Sakthivel Vaiyapuri | Zendy; Hervé Falet | Zendy; Ian M. Jones | Zendy; Alastair W. Poole | Zendy; Walter H.A. Kahr | Zendy; Jonathan M. Gibbins | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases

Author(s) -

Marilena Crescente,

Fred G. Pluthero,

Ling Li,

Richard Lo,

Tony G. Walsh,

Michael P. Schenk,

LisaMarie Holbrook,

Silvia Louriero,

Marfoua S. Ali,

Sakthivel Vaiyapuri,

Hervé Falet,

Ian M. Jones,

Alastair W. Poole,

Walter H.A. Kahr,

Jonathan M. Gibbins

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307461

Subject(s) - endoplasmic reticulum , protein disulfide isomerase , microbiology and biotechnology , calnexin , secretory pathway , platelet , biochemistry , platelet activation , chemistry , calreticulin , subcellular localization , brefeldin a , biology , golgi apparatus , cytoplasm , immunology

Thiol isomerases facilitate protein folding in the endoplasmic reticulum, and several of these enzymes, including protein disulfide isomerase and ERp57, are mobilized to the surface of activated platelets, where they influence platelet aggregation, blood coagulation, and thrombus formation. In this study, we examined the synthesis and trafficking of thiol isomerases in megakaryocytes, determined their subcellular localization in platelets, and identified the cellular events responsible for their movement to the platelet surface on activation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research