Type 1 Deiodinase Regulates ApoA-I Gene Expression and ApoA-I Synthesis Independent of Thyroid Hormone Signaling | Zendy

Jing Liu | Zendy; Antonio HernándezOno | Zendy; Mark J. Graham | Zendy; Valerie Anne Galton | Zendy; Henry N. Ginsberg | Zendy

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Type 1 Deiodinase Regulates ApoA-I Gene Expression and ApoA-I Synthesis Independent of Thyroid Hormone Signaling

Author(s) -

Jing Liu,

Antonio HernándezOno,

Mark J. Graham,

Valerie Anne Galton,

Henry N. Ginsberg

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307330

Subject(s) - deiodinase , dio2 , endocrinology , hormone , medicine , iodothyronine deiodinase , thyroid , thyroid hormone receptor , gene , signal transduction , gene expression , biology , chemistry , thyroid hormones , microbiology and biotechnology , genetics

Plasma levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) are reduced in individuals with defective insulin signaling. Initial studies using liver-specific insulin receptor (InsR) knockout mice identified reduced expression of type 1 deiodinase (Dio1) as a potentially novel link between defective hepatic insulin signaling and reduced expression of the ApoA-I gene. Our objective was to examine the regulation of ApoA-I expression by Dio1.

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