Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis | Zendy

Michael Keegan Delaney | Zendy; Kyungho Kim | Zendy; Brian Estevez | Zendy; Zheng Xu | Zendy; Aleksandra StojanovicTerpo | Zendy; Bo Shen | Zendy; Masuko UshioFukai | Zendy; Jaehyung Cho | Zendy; Xiaoping Du | Zendy

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Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis

Author(s) -

Michael Keegan Delaney,

Kyungho Kim,

Brian Estevez,

Zheng Xu,

Aleksandra StojanovicTerpo,

Bo Shen,

Masuko UshioFukai,

Jaehyung Cho,

Xiaoping Du

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307308

Subject(s) - thrombosis , nadph oxidase , platelet , platelet activation , medicine , chemistry , immunology , biochemistry , enzyme

Reactive oxygen species (ROS) are known to regulate platelet activation; however, the mechanisms of ROS production during platelet activation remain unclear. Platelets express different isoforms of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidases (NOXs). Here, we investigated the role of NOX1 and NOX2 in ROS generation and platelet activation using NOX1 and NOX2 knockout mice.

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