Serum Angiopoietin–Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community | Zendy

Jun Hata | Zendy; Naoko Mukai | Zendy; Masaharu Nagata | Zendy; Tomoyuki Ohara | Zendy; Daigo Yoshida | Zendy; Hiro Kishimoto | Zendy; Mao Shibata | Zendy; Yoichiro Hirakawa | Zendy; Motoyoshi Endo | Zendy; Tetsuro Ago | Zendy; Takanari Kitazono | Zendy; Yuichi Oike | Zendy; Yutaka Kiyohara | Zendy; Toshiharu Ninomiya | Zendy

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Serum Angiopoietin–Like Protein 2 Is a Novel Risk Factor for Cardiovascular Disease in the Community

Author(s) -

Jun Hata,

Naoko Mukai,

Masaharu Nagata,

Tomoyuki Ohara,

Daigo Yoshida,

Hiro Kishimoto,

Mao Shibata,

Yoichiro Hirakawa,

Motoyoshi Endo,

Tetsuro Ago,

Takanari Kitazono,

Yuichi Oike,

Yutaka Kiyohara,

Toshiharu Ninomiya

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307291

Subject(s) - medicine , confidence interval , quartile , insulin resistance , risk factor , hazard ratio , population , proportional hazards model , endocrinology , c reactive protein , metabolic syndrome , proinflammatory cytokine , cohort , diabetes mellitus , gastroenterology , inflammation , environmental health

Angiopoietin-like protein 2 (ANGPTL2), a proinflammatory mediator, has been reported to accelerate the development of insulin resistance, endothelial dysfunction, and atherosclerosis in mice. However, no cohort studies have examined the relationship between serum ANGPTL2 levels and the development of cardiovascular disease (CVD) in a general population.

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