miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux | Zendy

Mireille Ouimet | Zendy; Elizabeth J. Hennessy | Zendy; Coen van Solingen | Zendy; Graeme J. Koelwyn | Zendy; Maryem A. Hussein | Zendy; Bhama Ramkhelawon | Zendy; Katey J. Rayner | Zendy; Ryan E. Temel | Zendy; Ljubica Perisic | Zendy; Ulf Hedin | Zendy; Lars Mäegdefessel | Zendy; Michael J. Garabedian | Zendy; Lesca M. Holdt | Zendy; Daniel Teupser | Zendy; Kathryn J. Moore | Zendy

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miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux

Author(s) -

Mireille Ouimet,

Elizabeth J. Hennessy,

Coen van Solingen,

Graeme J. Koelwyn,

Maryem A. Hussein,

Bhama Ramkhelawon,

Katey J. Rayner,

Ryan E. Temel,

Ljubica Perisic,

Ulf Hedin,

Lars Mäegdefessel,

Michael J. Garabedian,

Lesca M. Holdt,

Daniel Teupser,

Kathryn J. Moore

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307282

Subject(s) - endoplasmic reticulum , microbiology and biotechnology , oxysterol , biology , endosome , cholesterol , liver x receptor , microrna , gene knockdown , homeostasis , nuclear receptor , biochemistry , gene , transcription factor , intracellular

Cholesterol homeostasis is fundamental to human health and is, thus, tightly regulated. MicroRNAs exert potent effects on biological pathways, including cholesterol metabolism, by repressing genes with related functions. We reasoned that this mode of pathway regulation could be exploited to identify novel genes involved in cholesterol homeostasis.

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