α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide–Dependent SIRT1 Activity | Zendy

Dongjie Li | Zendy; Fang Huang | Zendy; Min Ni | Zendy; Hui Fu | Zendy; Liangsheng Zhang | Zendy; FuMing Shen | Zendy

Open Access

α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide–Dependent SIRT1 Activity

Author(s) -

Dongjie Li,

Fang Huang,

Min Ni,

Hui Fu,

Liangsheng Zhang,

FuMing Shen

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.116.307157

Subject(s) - angiotensin ii , downregulation and upregulation , nad+ kinase , sirtuin 1 , senescence , vascular smooth muscle , chemistry , nadph oxidase , nad(p)h oxidase , microbiology and biotechnology , nicotinamide adenine dinucleotide phosphate , signal transduction , nicotinamide phosphoribosyltransferase , reactive oxygen species , receptor , endocrinology , medicine , biology , oxidase test , biochemistry , enzyme , smooth muscle , gene

α7 nicotinic acetylcholine receptor (α7nAChR) is a subtype of nAChR and has been reported to be involved in hypertension end-organ damage. In this study, we tested the role of α7nAChR in angiotensin II (Ang II)-induced senescence of vascular smooth muscle cells (VSMCs).

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