Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y 2 in Mice | Zendy

Peter Stachon | Zendy; Serjosha Geis | Zendy; Alexander Peikert | Zendy; Adrian Heidenreich | Zendy; Nathaly Anto Michel | Zendy; Fatih Ünal | Zendy; Natalie Hoppe | Zendy; Bianca Dufner | Zendy; Lisa Schulte | Zendy; Timoteo Marchini | Zendy; Sanja Cicko | Zendy; Cemil Korcan Ayata | Zendy; Andreas Zech | Zendy; Dennis Wolf | Zendy; Ingo Hilgendorf | Zendy; Florian Willecke | Zendy; Jochen Reinöhl | Zendy; Constantin von zur Mühlen | Zendy; Christoph Bode | Zendy; Marco Idzko | Zendy; Andreas Zirlik | Zendy

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Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y ₂ in Mice

Author(s) -

Peter Stachon,

Serjosha Geis,

Alexander Peikert,

Adrian Heidenreich,

Nathaly Anto Michel,

Fatih Ünal,

Natalie Hoppe,

Bianca Dufner,

Lisa Schulte,

Timoteo Marchini,

Sanja Cicko,

Cemil Korcan Ayata,

Andreas Zech,

Dennis Wolf,

Ingo Hilgendorf,

Florian Willecke,

Jochen Reinöhl,

Constantin von zur Mühlen,

Christoph Bode,

Marco Idzko,

Andreas Zirlik

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307397

Subject(s) - purinergic receptor , inflammation , extracellular , purinergic signalling , receptor , biology , medicine , chemistry , microbiology and biotechnology , endocrinology , adenosine receptor , agonist

A solid body of evidence supports a role of extracellular ATP and its P2 receptors in innate and adaptive immunity. It promotes inflammation as a danger signal in various chronic inflammatory diseases. Thus, we hypothesize contribution of extracellular ATP and its receptor P2Y2 in vascular inflammation and atherosclerosis.

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