c-Myb Regulates Proliferation and Differentiation of Adventitial Sca1 + Vascular Smooth Muscle Cell Progenitors by Transactivation of Myocardin | Zendy

Eric A. Shikatani | Zendy; Mark Chandy | Zendy; Rickvinder Besla | Zendy; Cedric C. Li | Zendy; Abdul Momen | Zendy; Omar El-Mounayri | Zendy; Clinton S. Robbins | Zendy; Mansoor Husain | Zendy

Open Access

c-Myb Regulates Proliferation and Differentiation of Adventitial Sca1 ⁺ Vascular Smooth Muscle Cell Progenitors by Transactivation of Myocardin

Author(s) -

Eric A. Shikatani,

Mark Chandy,

Rickvinder Besla,

Cedric C. Li,

Abdul Momen,

Omar El-Mounayri,

Clinton S. Robbins,

Mansoor Husain

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307116

Subject(s) - myocardin , biology , progenitor cell , vascular smooth muscle , microbiology and biotechnology , cellular differentiation , stem cell , transcription factor , endocrinology , serum response factor , biochemistry , smooth muscle , gene

Vascular smooth muscle cells (VSMCs) are believed to dedifferentiate and proliferate in response to vessel injury. Recently, adventitial progenitor cells were implicated as a source of VSMCs involved in vessel remodeling. c-Myb is a transcription factor known to regulate VSMC proliferation in vivo and differentiation of VSMCs from mouse embryonic stem cell-derived progenitors in vitro. However, the role of c-Myb in regulating specific adult vascular progenitor cell populations was not known. Our objective was to examine the role of c-Myb in the proliferation and differentiation of Sca1(+) adventitial VSMC progenitor cells.

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