PDK1 Determines Collagen-Dependent Platelet Ca 2+ Signaling and Is Critical to Development of Ischemic Stroke In Vivo | Zendy

Patrick Münzer | Zendy; Britta Walker-Allgaier | Zendy; Sascha Geue | Zendy; Eva Geuß | Zendy; Gregor Hron | Zendy; Dominik Rath | Zendy; Daniela Eißler | Zendy; Stefan Winter | Zendy; Elke Schaeffeler | Zendy; Monika Meinert | Zendy; Martin Schaller | Zendy; Andreas Greinacher | Zendy; Matthias Schwab | Zendy; Tobias Geisler | Zendy; Christoph Kleinschnitz | Zendy; Florian Läng | Zendy; Meinrad Gawaz | Zendy; Oliver Borst | Zendy

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PDK1 Determines Collagen-Dependent Platelet Ca ²⁺ Signaling and Is Critical to Development of Ischemic Stroke In Vivo

Author(s) -

Patrick Münzer,

Britta Walker-Allgaier,

Sascha Geue,

Eva Geuß,

Gregor Hron,

Dominik Rath,

Daniela Eißler,

Stefan Winter,

Elke Schaeffeler,

Monika Meinert,

Martin Schaller,

Andreas Greinacher,

Matthias Schwab,

Tobias Geisler,

Christoph Kleinschnitz,

Florian Läng,

Meinrad Gawaz,

Oliver Borst

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307105

Subject(s) - in vivo , platelet , ischemic stroke , stroke (engine) , medicine , cardiology , microbiology and biotechnology , chemistry , ischemia , biology , physics , genetics , thermodynamics

Activation of platelets by subendothelial collagen results in an increase of cytosolic Ca(2+) concentration ([Ca(2+)]i) and is followed by platelet activation and thrombus formation that may lead to vascular occlusion. The present study determined the role of phosphoinositide-dependent protein kinase 1 (PDK1) in collagen-dependent platelet Ca(2+) signaling and ischemic stroke in vivo.

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