Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway | Zendy

Daniel Castranova | Zendy; Andrew Davis | Zendy; Brigid D. Lo | Zendy; Mayumi F. Miller | Zendy; Paul J. Paukstelis | Zendy; Matthew Swift | Zendy; Van N. Pham | Zendy; Jesús TorresVázquez | Zendy; Kameha Bell | Zendy; Kenna M. Shaw | Zendy; Makoto Kamei | Zendy; Brant M. Weinstein | Zendy

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Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway

Author(s) -

Daniel Castranova,

Andrew Davis,

Brigid D. Lo,

Mayumi F. Miller,

Paul J. Paukstelis,

Matthew Swift,

Van N. Pham,

Jesús TorresVázquez,

Kameha Bell,

Kenna M. Shaw,

Makoto Kamei,

Brant M. Weinstein

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307087

Subject(s) - unfolded protein response , atf6 , xbp1 , endoplasmic reticulum , angiogenesis , microbiology and biotechnology , downregulation and upregulation , atf4 , biology , protein biosynthesis , protein kinase a , integrated stress response , protein kinase r , transcription factor , signal transduction , rna , zebrafish , chemistry , kinase , messenger rna , biochemistry , cancer research , mitogen activated protein kinase kinase , translation (biology) , gene , rna splicing

Understanding the mechanisms regulating normal and pathological angiogenesis is of great scientific and clinical interest. In this report, we show that mutations in 2 different aminoacyl-transfer RNA synthetases, threonyl tRNA synthetase (tars(y58)) or isoleucyl tRNA synthetase (iars(y68)), lead to similar increased branching angiogenesis in developing zebrafish.

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