Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes | Zendy

Norbert Gerdes | Zendy; Tom Seijkens | Zendy; Dirk Lievens | Zendy; Marijke J. E. Kuijpers | Zendy; Holger Winkels | Zendy; Delia Projahn | Zendy; Helene Hartwig | Zendy; Linda Beckers | Zendy; Remco T. A. Megens | Zendy; Louis Boon | Zendy; Randolph J. Noelle | Zendy; Oliver Soehnlein | Zendy; Johan W. M. Heemskerk | Zendy; Christian Weber | Zendy; Esther Lutgens | Zendy

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Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes

Author(s) -

Norbert Gerdes,

Tom Seijkens,

Dirk Lievens,

Marijke J. E. Kuijpers,

Holger Winkels,

Delia Projahn,

Helene Hartwig,

Linda Beckers,

Remco T. A. Megens,

Louis Boon,

Randolph J. Noelle,

Oliver Soehnlein,

Johan W. M. Heemskerk,

Christian Weber,

Esther Lutgens

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307074

Subject(s) - platelet , cd40 , platelet activation , inflammation , cell adhesion molecule , hemostasis , p selectin , platelet adhesiveness , endothelium , immunology , chemistry , medicine , biochemistry , in vitro , platelet aggregation , cytotoxic t cell

Beyond their eminent role in hemostasis and thrombosis, platelets are recognized as mediators of inflammation. Platelet cluster of differentiation 40 (CD40) ligand (CD40L and CD154) plays a key role in mediating platelet-induced inflammation in atherosclerosis. CD40, the receptor for CD40L, is present on platelets; however, the role of CD40 on this cell type is until now undefined.

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