Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection | Zendy

Jonas Brinck | Zendy; Aurélien Thomas | Zendy; Estelle Lauer | Zendy; François R. Jornayvaz | Zendy; MarieClaude BrulhartMeynet | Zendy; JeanChristophe Prost | Zendy; Zoltan Pataky | Zendy; Patrik Löfgren | Zendy; Johan Hoffstedt | Zendy; Mats Eriksson | Zendy; Camilla Pramfalk | Zendy; Sandrine Morel | Zendy; Brenda R. Kwak | Zendy; Miranda Van Eck | Zendy; Richard W. James | Zendy; Miguel A. Frias | Zendy

Open Access

Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection

Author(s) -

Jonas Brinck,

Aurélien Thomas,

Estelle Lauer,

François R. Jornayvaz,

MarieClaude BrulhartMeynet,

JeanChristophe Prost,

Zoltan Pataky,

Patrik Löfgren,

Johan Hoffstedt,

Mats Eriksson,

Camilla Pramfalk,

Sandrine Morel,

Brenda R. Kwak,

Miranda Van Eck,

Richard W. James,

Miguel A. Frias

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307049

Subject(s) - glycation , medicine , endocrinology , glycated hemoglobin , diabetes mellitus , oxidative stress , high density lipoprotein , lipoprotein , type 2 diabetes , cholesterol

The dyslipidemia of type 2 diabetes mellitus has multiple etiologies and impairs lipoprotein functionality, thereby increasing risk for cardiovascular disease. High-density lipoproteins (HDLs) have several beneficial effects, notably protecting the heart from myocardial ischemia. We hypothesized that glycation of HDL could compromise this cardioprotective effect.

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