Intravenous Glucose Acutely Stimulates Intestinal Lipoprotein Secretion in Healthy Humans | Zendy

Changting Xiao | Zendy; Satya Dash | Zendy; Cecilia Morgantini | Zendy; Gary F. Lewis | Zendy

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Intravenous Glucose Acutely Stimulates Intestinal Lipoprotein Secretion in Healthy Humans

Author(s) -

Changting Xiao,

Satya Dash,

Cecilia Morgantini,

Gary F. Lewis

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307044

Subject(s) - medicine , endocrinology , lipoprotein particle , lipoprotein , apolipoprotein b , insulin , triglyceride , hyperinsulinemia , glucagon , diabetes mellitus , type 2 diabetes , insulin resistance , very low density lipoprotein , cholesterol

Increased production of intestinal triglyceride-rich lipoproteins (TRLs) contributes to dyslipidemia and increased risk of atherosclerotic cardiovascular disease in insulin resistance and type 2 diabetes. We have previously demonstrated that enteral glucose enhances lipid-stimulated intestinal lipoprotein particle secretion. Here, we assessed whether glucose delivered systemically by intravenous infusion also enhances intestinal lipoprotein particle secretion in humans.

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