Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis—Brief Report | Zendy

Xiaofeng Chen | Zendy; Deborah A. Howatt | Zendy; Anju Balakrishnan | Zendy; Jessica J. Moorleghen | Zendy; Congqing Wu | Zendy; Lisa A. Cassis | Zendy; Alan Daugherty | Zendy; Hong Lü | Zendy

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Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis—Brief Report

Author(s) -

Xiaofeng Chen,

Deborah A. Howatt,

Anju Balakrishnan,

Jessica J. Moorleghen,

Congqing Wu,

Lisa A. Cassis,

Alan Daugherty,

Hong Lü

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307038

Subject(s) - angiotensin ii , enzyme , vascular smooth muscle , medicine , angiotensin converting enzyme , smooth muscle , endocrinology , renin–angiotensin system , biology , cardiology , biochemistry , receptor , blood pressure

Angiotensin-converting enzyme (ACE) is present in many cell types of atherosclerotic lesions. This study determined whether ACE activity in endothelial and smooth muscle cells (SMCs), 2 major resident cell types of the aorta, contributes to hypercholesterolemia-induced atherosclerosis.

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