Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow | Zendy

Jevgenia ZilbermanRudenko | Zendy; Asako Itakura | Zendy; Chantal P Wiesenekker | Zendy; R. L. Vetter | Zendy; Coen Maas | Zendy; David Gailani | Zendy; Erik I. Tucker | Zendy; András Gruber | Zendy; Christoph Gerdes | Zendy; Owen J. T. McCarty | Zendy

Open Access

Coagulation Factor XI Promotes Distal Platelet Activation and Single Platelet Consumption in the Bloodstream Under Shear Flow

Author(s) -

Jevgenia ZilbermanRudenko,

Asako Itakura,

Chantal P Wiesenekker,

R. L. Vetter,

Coen Maas,

David Gailani,

Erik I. Tucker,

András Gruber,

Christoph Gerdes,

Owen J. T. McCarty

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307034

Subject(s) - thrombus , platelet , coagulation , thrombin , fibrin , chemistry , tissue factor , platelet activation , ex vivo , platelet adhesiveness , microbiology and biotechnology , immunology , medicine , biochemistry , in vitro , biology , platelet aggregation

Coagulation factor XI (FXI) has been shown to contribute to thrombus formation on collagen or tissue factor-coated surfaces in vitro and in vivo by enhancing thrombin generation. Whether the role of the intrinsic pathway of coagulation is restricted to the local site of thrombus formation is unknown. This study was aimed to determine whether FXI could promote both proximal and distal platelet activation and aggregate formation in the bloodstream.

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