Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo | Zendy

Klaudia Schossleitner | Zendy; Sabine Rauscher | Zendy; Marion Gröger | Zendy; Heinz P. Friedl | Zendy; Richard Finsterwalder | Zendy; Andreas Habertheuer | Zendy; Maria Sibilia | Zendy; Christine Brostjan | Zendy; Dagmar Födinger | Zendy; Sandra Citi | Zendy; Peter Petzelbauer | Zendy

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Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo

Author(s) -

Klaudia Schossleitner,

Sabine Rauscher,

Marion Gröger,

Heinz P. Friedl,

Richard Finsterwalder,

Andreas Habertheuer,

Maria Sibilia,

Christine Brostjan,

Dagmar Födinger,

Sandra Citi,

Peter Petzelbauer

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307032

Subject(s) - tight junction , microbiology and biotechnology , biology , barrier function , endothelial stem cell , in vitro , biochemistry

Cingulin is a cytoplasmic component of tight junctions. Although modulation of cingulin levels in cultured epithelial model systems has no significant effect on barrier function, evidence from cingulin knockout mice suggests that cingulin may be involved in the regulation of the behavior of epithelial or endothelial cells. Here, we investigate the role of cingulin in the barrier function of endothelial cells.

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