Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κB Pathways | Zendy

Jianyong Sun | Zendy; Chao Li | Zendy; ZhuXia Shen | Zendy; WuChang Zhang | Zendy; Tang-Jun Ai | Zendy; LinJuan Du | Zendy; Yuyao Zhang | Zendy; Gao-Feng Yao | Zendy; Yan Liu | Zendy; Shuyang Sun | Zendy; Anikó NárayFejesTóth | Zendy; Géza FejesTóth | Zendy; Yong Peng | Zendy; Mao Chen | Zendy; Xiaojing Liu | Zendy; Jun Tao | Zendy; Bin Zhou | Zendy; Ying Yu | Zendy; Feifan Guo | Zendy; Jie Du | Zendy; ShengZhong Duan | Zendy

Open Access

Mineralocorticoid Receptor Deficiency in Macrophages Inhibits Neointimal Hyperplasia and Suppresses Macrophage Inflammation Through SGK1-AP1/NF-κB Pathways

Author(s) -

Jianyong Sun,

Chao Li,

ZhuXia Shen,

WuChang Zhang,

Tang-Jun Ai,

LinJuan Du,

Yuyao Zhang,

Gao-Feng Yao,

Yan Liu,

Shuyang Sun,

Anikó NárayFejesTóth,

Géza FejesTóth,

Yong Peng,

Mao Chen,

Xiaojing Liu,

Jun Tao,

Bin Zhou,

Ying Yu,

Feifan Guo,

Jie Du,

ShengZhong Duan

Publication year - 2016

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307031

Subject(s) - proinflammatory cytokine , neointimal hyperplasia , inflammation , vascular smooth muscle , endocrinology , medicine , macrophage , cancer research , restenosis , biology , biochemistry , smooth muscle , stent , in vitro

Restenosis after percutaneous coronary intervention remains to be a serious medical problem. Although mineralocorticoid receptor (MR) has been implicated as a potential target for treating restenosis, the cellular and molecular mechanisms are largely unknown. This study aims to explore the functions of macrophage MR in neointimal hyperplasia and to delineate the molecular mechanisms.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research