Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling | Zendy

Stephen P. Gray | Zendy; Elyse Di Marco | Zendy; Kit Kennedy | Zendy; Phyllis Chew | Zendy; Jun Okabe | Zendy; Assam ElOsta | Zendy; Anna C. Calkin | Zendy; Erik A.L. Biessen | Zendy; Rhian M. Touyz | Zendy; Mark E. Cooper | Zendy; Harald Schmidt | Zendy; Karin JandeleitDahm | Zendy

Open Access

Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling

Author(s) -

Stephen P. Gray,

Elyse Di Marco,

Kit Kennedy,

Phyllis Chew,

Jun Okabe,

Assam ElOsta,

Anna C. Calkin,

Erik A.L. Biessen,

Rhian M. Touyz,

Mark E. Cooper,

Harald Schmidt,

Karin JandeleitDahm

Publication year - 2015

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.115.307012

Subject(s) - inflammation , reactive oxygen species , nox4 , proinflammatory cytokine , microbiology and biotechnology , chemistry , medicine , biology , immunology , nadph oxidase

Oxidative stress is considered a hallmark of atherosclerosis. In particular, the superoxide-generating type 1 NADPH oxidase (NOX1) has been shown to be induced and play a pivotal role in early phases of mouse models of atherosclerosis and in the context of diabetes mellitus. Here, we investigated the role of the most abundant type 4 isoform (NOX4) in human and mouse advanced atherosclerosis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research